研究業績

総説(英文)

Shimano H, Sato R.
SREBP-regulated lipid metabolism: convergent physiology – divergent pathophysiology.
Nat Rev Endocrinol. 13(12):710-730, 2017.

原著(英文)

Furukawa S, Suzuki H, Fujihara K, Kobayashi K, Iwasaki H, Sugano Y, Yatoh S, Sekiya M, Yahagi N, Shimano H.
Malondialdehyde-modified LDL-related variables are associated with diabetic kidney disease in type 2 diabetes.
Diabetes Res Clin Pract. 141:237-243, 2018.

Takeuchi Y, Yahagi N, Aita Y, Murayama Y, Sawada Y, Piao X, Toya N, Oya Y, Shikama A, Takarada A, Masuda Y, Nishi M, Kubota M, Izumida Y, Yamamoto T, Sekiya M, Matsuzaka T, Nakagawa Y, Urayama O, Kawakami Y, Iizuka Y, Gotoda T, Itaka K, Kataoka K, Nagai R, Kadowaki T, Yamada N, Lu Y, Jain MK, Shimano H.
KLF15 Enables Rapid Switching between Lipogenesis and Gluconeogenesis during Fasting.
Cell Rep. 16(9):2373-86, 2016.

Nakagawa Y, Satoh A, Yabe S, Furusawa M, Tokushige N, Tezuka H, Mikami M, Iwata W, Shingyouchi A, Matsuzaka T, Kiwata S, Fujimoto Y, Shimizu H, Danno H, Yamamoto T, Ishii K, Karasawa T, Takeuchi Y, Iwasaki H, Shimada M, Kawakami Y, Urayama O, Sone H, Takekoshi K, Kobayashi K, Yatoh S, Takahashi A, Yahagi N, Suzuki H, Yamada N, Shimano H.
Hepatic CREB3L3 controls whole-body energy homeostasis and improves obesity and diabetes.
Endocrinology. 155(12):4706-19, 2014.

Matsuzaka T, Shimano H, Yahagi N, Kato T, Atsumi A, Yamamoto T, Inoue N, Ishikawa M, Okada S, Ishigaki N, Iwasaki H, Iwasaki Y, Karasawa T, Kumadaki S, Matsui T, Sekiya M, Ohashi K, Hasty AH, Nakagawa Y, Takahashi A, Suzuki H, Yatoh S, Sone H, Toyoshima H, Osuga J, Yamada N.
Crucial role of a long-chain fatty acid elongase, Elovl6, in obesity-induced insulin resistance.
Nat Med. 13(10):1193-202, 2007.

Nakagawa Y, Shimano H, Yoshikawa T, Ide T, Tamura M, Furusawa M, Yamamoto T, Inoue N, Matsuzaka T, Takahashi A, Hasty AH, Suzuki H, Sone H, Toyoshima H, Yahagi N, Yamada N.
TFE3 transcriptionally activates hepatic IRS-2, participates in insulin signaling and ameliorates diabetes.
Nat Med. 12(1):107-13, 2006.

Sekiya M, Yahagi N, Matsuzaka T, Najima Y, Nakakuki M, Nagai R, Ishibashi S, Osuga J, Yamada N, Shimano H.
Polyunsaturated fatty acids ameliorate hepatic steatosis in obese mice by SREBP-1 suppression.
Hepatology. 38(6):1529-39, 2003.

Shimano H, Horton JD, Hammer RE, Shimomura I, Brown MS, Goldstein JL.
Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a.
J Clin Invest. 98(7):1575-84, 1996.

総説(和文)

脂質の質に視点を置いた臓器障害治療戦略と創薬 : SREBP-1cとElovl6
Shimano H.
Yakugaku Zasshi. 35(9):1003-9. doi: 10.1248/yakushi.15-00175-1, 2015.

著書

島野 仁
SREBPによる脂質代謝調節(第2章 病因と病態生理)
TG血症(診断と治療のABC)、最新医学者、pp.67-74, 2018.

PubMedへのリンク

Shimano H[Author], University of Tsukuba[Affiliation]