筑波大学内分泌代謝・糖尿病内科の研究業績を掲載しています。

Matsuda E, Matsuda T, Kojo K, Osaki Y, Suzuki Y, Suzuki H, Mathis B, Sekiya M, Nishiyama H, Shimano H.

Branched-Chain Amino Acids and Testosterone in Older Adults With Type 2 Diabetes: Cross-Sectional and Longitudinal Findings From a Post Hoc Analysis of an Amino Acid Supplementation Trial. Cureus. 2025 Sep 12;17(9):e92180.

Sekiya M, Kainoh K, Chen W, Yamazaki D, Tsuyuzaki T, Kobari Y, Nakata A, Saito K, Aono-Soma N, Majid A, Ohno H, Miyamoto T, Matsuzaka T, Nakajima R, Matsuda T, Murayama Y, Sugano Y, Osaki Y, Iwasaki H, Shimano H.

The secreted metabolite sensor CtBP2 links metabolism to healthy lifespan. Nat Aging. 2025 Oct 8. 

Matsuda T, Osaki Y, Matsumoto N, Nakajima R, Murayama Y, Sugano Y, Iwasaki H, Mathis BJ, Sekiya M, Shimano H.

Evinacumab Improved the Homozygous Familial Hypercholesterolemia Lipid Metabolism: A Case Report. J Atheroscler Thromb. 2025 Oct 8. 

Matsuda E, Hasebe S, Matsuzaka T, Hayashi A, Ohno H, Motomura K, Sakka S, Kohno S, Muranaka H, Yamamura M, Suzuki A, Takeuchi Y, Osaki Y, Miyamoto T, Sekiya M, Sone H, Yahagi N, Nakagawa Y, Nitta S, Kandori S, Kojima T, Takahashi C, Nishiyama H, Shimano H.

Inhibition of ELOVL6 activity impairs mitochondrial respiratory function and inhibits tumor progression in FGFR3-mutated bladder cancer cells. Biochim Biophys Acta Mol Basis Dis. 2025 Nov;1871(8):168023.

Suzuki Y, Suzuki H, Ishikawa T, Yamada Y, Yatoh S, Sugano Y, Iwasaki H, Sekiya M, Yahagi N, Hada Y, Shimano H.

Exploratory analysis using machine learning of predictive factors for falls in type 2 diabetes. Sci Rep. 2022 Jul 13;12(1):11965.

Sekiya M, Yuhara M, Murayama Y, Ohyama Osawa M, Nakajima R, Ohuchi N, Matsumoto N, Yamazaki D, Mori S, Matsuda T, Sugano Y, Osaki Y, Iwasaki H, Suzuki H, Shimano H.

A case of early-onset diabetes with impaired insulin secretion carrying a PAX6 gene Gln135* mutation. Endocrinol Diabetes Metab Case Rep. 2022 Aug 1;2022:22-0271. 

Matsuda T, Suzuki H, Sugano Y, Suzuki Y, Yamanaka D, Araki R, Yahagi N, Sekiya M, Kawakami Y, Osaki Y, Iwasaki H, Hashimoto K, Takahashi SI, Hada Y, Shimano H.

Effects of Branched-Chain Amino Acids on Skeletal Muscle, Glycemic Control, and Neuropsychological Performance in Elderly Persons with Type 2 Diabetes Mellitus: An Exploratory Randomized Controlled Trial. Nutrients. 2022 Sep 21;14(19):3917. 

Araki M, Nakagawa Y, Saito H, Yamada Y, Han SI, Mizunoe Y, Ohno H, Miyamoto T, Sekiya M, Matsuzaka T, Sone H, Shimano H.

Hepatocyte- or macrophage-specific SREBP-1a deficiency in mice exacerbates methionine- and choline-deficient diet-induced nonalcoholic fatty liver disease. Am J Physiol Gastrointest Liver Physiol. 2022 Dec 1;323(6):G627-G639. 

Furuta Y, Yatoh S, Iwasaki H, Sugano Y, Sekiya M, Suzuki H, Shimano H.

L-Asparaginase-Induced Continuous Hyperglycemia With Type 1 Diabetes-Related Antibodies and HLA Genotypes: A Case Study. Cureus. 2022 Oct 8;14(10):e30067. 

Nakajima R, Sekiya M, Furuta Y, Miyamoto T, Sato M, Fukuda K, Hattori K, Suehara Y, Sakata-Yanagimoto M, Chiba S, Okajima Y, Matsuzaka T, Takase S, Takanashi M, Okazaki H, Takashima Y, Yuhara M, Mitani Y, Matsumoto N, Murayama Y, Ohyama Osawa M, Ohuchi N, Yamazaki D, Mori S, Sugano Y, Osaki Y, Iwasaki H, Suzuki H, Shimano H.

A case of NASH with genetic predisposition successfully treated with an SGLT2 inhibitor: a possible involvement of mitochondrial dysfunction. Endocrinol Diabetes Metab Case Rep. 2022 Dec 1;2022:22-0368. 

Yamazaki D, Osaki Y, Suzuki H, Shimano H.

 Takotsubo cardiomyopathy with left ventricle thrombus caused by subacute thyroiditis. BMJ Case Rep. 2023 Mar 14;16(3):e250540. 

Saito K, Sekiya M, Kainoh K, Yoshino R, Hayashi A, Han SI, Araki M, Ohno H, Takeuchi Y, Tsuyuzaki T, Yamazaki D, Wanpei C, Hada L, Watanabe S, Paramita Adi Putri PI, Murayama Y, Sugano Y, Osaki Y, Iwasaki H, Yahagi N, Suzuki H, Miyamoto T, Matsuzaka T, Shimano H.

Obesity-induced metabolic imbalance allosterically modulates CtBP2 to inhibit PPAR-alpha transcriptional activity. J Biol Chem. 2023 Jul;299(7):104890. 

Sekiya M, Ma Y, Kainoh K, Saito K, Yamazaki D, Tsuyuzaki T, Chen W, Adi Putri PIP, Ohno H, Miyamoto T, Takeuchi Y, Murayama Y, Sugano Y, Osaki Y, Iwasaki H, Yahagi N, Suzuki H, Motomura K, Matsuzaka T, Murata K, Mizuno S, Takahashi S, Shimano H.

Loss of CtBP2 may be a mechanistic link between metabolic derangements and progressive impairment of pancreatic β cell function. Cell Rep. 2023 Aug 29;42(8):112914.

Sekiya M, Kainoh K, Saito K, Yamazaki D, Tsuyuzaki T, Chen W, Kobari Y, Nakata A, Babe H, Shimano H.

 C-Terminal Binding Protein 2 Emerges as a Critical Player Linking Metabolic Imbalance to the Pathogenesis of Obesity. J Atheroscler Thromb. 2024 Feb 1;31(2):109-116. 

Motomura K, Matsuzaka T, Shichino S, Ogawa T, Pan H, Nakajima T, Asano Y, Okayama T, Takeuchi T, Ohno H, Han SI, Miyamoto T, Takeuchi Y, Sekiya M, Sone H, Yahagi N, Nakagawa Y, Oda T, Ueha S, Ikeo K, Ogura A, Matsushima K, Shimano H.

Single-Cell Transcriptome Profiling of Pancreatic Islets From Early Diabetic Mice Identifies Anxa10 for Ca2+ Allostasis Toward β-Cell Failure. Diabetes. 2024 Jan 1;73(1):75-92.