筑波大学内分泌代謝・糖尿病内科の研究業績を掲載しています。

Han SI, Nakakuki M, Nakagawa Y, Wang Y, Araki M, Yamamoto Y, Tokiwa H, Takeda H, Mizunoe Y, Motomura K, Ohno H, Kainoh K, Murayama Y, Aita Y, Takeuchi Y, Osaki Y, Miyamoto T, Sekiya M, Matsuzaka T, Yahagi N, Sone H, Daitoku H, Sato R, Kawano H, Shimano H.

Rhomboid protease RHBDL4/RHBDD1 cleaves SREBP-1c at endoplasmic reticulum monitoring and regulating fatty acids. PNAS Nexus. 2023 Nov 8;2(11):pgad351.

Furuta Y, Osaki Y, Nakagawa Y, Han SI, Araki M, Shikama A, Ohuchi N, Yamazaki D, Matsuda E, Nohara S, Mizunoe Y, Kainoh K, Suehara Y, Ohno H, Takeuchi Y, Miyamoto T, Murayama Y, Sugano Y, Iwasaki H, Hirano KI, Koseki M, Nakano S, Tokiwa H, Sekiya M, Yahagi N, Matsuzaka T, Nakamagoe K, Tomidokoro Y, Mitsui J, Tsuji S, Suzuki H, Shimano H.

Genetic and Functional Analyses of Patients with Marked Hypo-High-Density Lipoprotein Cholesterolemia. J Atheroscler Thromb. 2024 Sep 1;31(9):1304-1318. 

Matsuda T, Osaki Y, Maruo K, Matsuda E, Suzuki Y, Suzuki H, Mathis BJ, Shimano H, Mizutani M.

Variability of urinary albumin to creatinine ratio and eGFR are independently associated with eGFR slope in Japanese with type 2 diabetes: a three-year, single-center, retrospective cohort study. BMC Nephrol. 2024 Aug 16;25(1):264.

Matsuda T, Osaki Y, Sekiya M, Shimano H.

Paradoxical cerebral embolism caused by patent foramen ovale in a patient with multiple endocrine neoplasia type 1 and severe primary hyperparathyroidism. BMJ Case Rep. 2024 Nov 24;17(11):e261601. 

Iwasaki H, Yagyu H, Shimano H.

A Comprehensive Analysis of Diabetic Complications and Advances in Management Strategies. J Atheroscler Thromb. 2025

Suzuki Y, Suzuki H, Maruo K, Matsuda T, Murayama Y, Sugano Y, Osaki Y, Iwasaki H, Sekiya M, Hada Y, Shimano H.

Longitudinal association of SGLT2 inhibitors and GLP-1RAs on falls in persons with type 2 diabetes. Sci Rep. 2025 Mar 17;15(1):9178.

Sugano Y, Sekiya M, Murayama Y, Osaki Y, Iwasaki H, Suzuki H, Fukushima H, Suzuki H, Noguchi E, Shimano H.

Case-based learning: a case of maturity-onset diabetes of the young 5 (MODY5) due to 17q12 microdeletion with a diminished plasma glucagon level. Diabetol Int. 2025 Feb 17;16(2):432-438. 

Matsuda T, Osaki Y, Sekiya M, Shimano H.

Early insulin averts hyperglycemic crisis in slow-onset durvalumab-induced checkpoint inhibitor-associated autoimmune diabetes mellitus. J Rural Med. 2025 Apr;20(2):150-155.

Hosoda A, Arata N, Umehara N, Sato S, Sankoda A, Iimura Y, Mito A, Nagata C, Wada S, Kawaguchi H, Waguri M, Mitsuda N, Shimano H.

Prediction of fetal Graves’ disease among pregnant women with Graves’ disease who have undergone thyroidectomy or radioactive iodine therapy: A retrospective observational study. Endocr J. 2025 Jul 1;72(7):819-829. 

Matsuda T, Osaki Y, Soma N, Azuma T, Ezura A, Mitani Y, Kikuchi Y, Matsumoto N, Murayama Y, Sugano Y, Iwasaki H, Mathis BJ, Sekiya M, Shimano H.

A case of latent autoimmune diabetes in the young positive for zinc transporter 8 antibody with type 2 diabetes characteristics. Clin Pediatr Endocrinol. 2025 Jul;34(3):193-199.

Matsuda T, Osaki Y, Takahashi H, Matsuda E, Suzuki Y, Kojo K, Murayama Y, Sugano Y, Iwasaki H, Mathis BJ, Suzuki H, Sekiya M, Shimano H.

Reliability of Gait Analysis Using ORPHE ANALYTICS in Patients with Type 2 Diabetes: A Single-center Observational Study. JMA J. 2025 Jul 15;8(3):853-870. 

Okajima Y, Matsuzaka T, Miyazaki S, Motomura K, Ohno H, Sharma R, Shimura T, Istiqamah N, Han SI, Mizunoe Y, Osaki Y, Iwasaki H, Yatoh S, Suzuki H, Sone H, Miyamoto T, Aita Y, Takeuchi Y, Sekiya M, Yahagi N, Nakagawa Y, Tomita T, Shimano H.

Morphological and functional adaptation of pancreatic islet blood vessels to insulin resistance is impaired in diabetic db/db mice. Biochim Biophys Acta Mol Basis Dis. 2022 Jan 8;1868(4):166339. doi: 10.1016/j.bbadis.2022.166339. Epub ahead of print. PMID: 35017029.

Takeuchi Y, Yahagi N, Aita Y, Mehrazad-Saber Z, Ho MH, Huyan Y, Murayama Y, Shikama A, Masuda Y, Izumida Y, Miyamoto T, Matsuzaka T, Kawakami Y, Shimano H.

FoxO-KLF15 pathway switches the flow of macronutrients under the control of insulin. iScience. 2021 Nov 15;24(12):103446. doi: 10.1016/j.isci.2021.103446. PMID: 34988390; PMCID: PMC8710527.

Sekiya M, Kainoh K, Sugasawa T, Yoshino R, Hirokawa T, Tokiwa H, Nakano S, Nagatoishi S, Tsumoto K, Takeuchi Y, Miyamoto T, Matsuzaka T, Shimano H.

The transcriptional corepressor CtBP2 serves as a metabolite sensor orchestrating hepatic glucose and lipid homeostasis. Nat Commun. 2021 Nov 2;12(1):6315. doi: 10.1038/s41467-021-26638-5. PMID: 34728642; PMCID: PMC8563733.

Midorikawa M, Suzuki H, Suzuki Y, Yamauchi K, Sato H, Nemoto K, Sugano Y, Iwasaki H, Sekiya M, Yatoh S, Yahagi N, Hada Y, Arai T, Shimano H.

Relationships between Cognitive Function and Odor Identification, Balance Capability, and Muscle Strength in Middle-Aged Persons with and without Type 2 Diabetes. J Diabetes Res. 2021 Oct 7;2021:9961612. doi: 10.1155/2021/9961612. PMID: 34660814; PMCID: PMC8516531.